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MonaVie - Wikipedia
MonaVie is a defunct, American multi-level marketing company that manufactured and distributed products made from blended fruit juice concentrates, powders, and purées company was the subject of several controversies. Health claims for its products had not been scientifically confirmed or approved by regulatory authorities, and its chairman had been previously
Haplogroup R1a - Wikipedia
Haplogroup R1a, or haplogroup R-M420, is a human Y-chromosome DNA haplogroup which is distributed in a large region in Eurasia, extending from Scandinavia and Central Europe to southern Siberia and South Asia. While R1a originated ca. 22,000 to 25,000 years ago, its subclade M417 (R1a1a1) diversified ca. 5,800 years ago. The place of origin of the subclade
Jurkat T cells and development of the T-cell receptor - Nature
Apr 01, 2004Emergence of the Jurkat model system. As is the case today, T-cell biologists in the early 1980s focused their research efforts mainly on cells of human or mouse origin.
JCI - Endothelial HIF-2 mediates protection and recovery from ischemic
May 01, 2014Pinelopi P. Kapitsinou, 1,2 Hideto Sano, 1,2 Mark Michael, 1,2 Hanako Kobayashi, 1,2 Olena Davidoff, 1,2 Aihua Bian, 3 Bing Yao, 1 Ming-Zhi Issue 6 on June 2, 2014 J Clin Invest. Renoprotection induced by systemic HIF prolyl-hydroxylase inhibition requires endothelial HIF-2. (A) Scheme of the experimental protocol and representative
Ancient plant-like terpene biosynthesis in corals
May 23, 2022One microliter of 20 mg ml –1 ErTC-2 in the lysis buffer was mixed with 1.0 μl of well solution (0 M Tris pH 8.5, 28% (wt/vol) PEG 3350, 0 M MgCl 2) to make a 2-μl sitting drop in a
Direct-to-Biology Accelerates PROTAC Synthesis and the
Jun 20, 2022A platform to accelerate optimization of proteolysis targeting chimeras (PROTACs) has been developed using a direct-to-biology (D2B) approach with a focus on linker effects. A large number of linker analogs─with varying length, polarity, and rigidity─were rapidly prepared and characterized in four cell-based assays by streamlining time-consuming steps in synthesis
Quinolone antibiotics - PMC
Oct 01, 20191. Introduction. The quinolones are a family of antibiotics containing a bicyclic core structure related to the compound 4-quinolone (Fig. 1).1 Since their discovery in the early 1960s, they have gained increasing importance as key therapies to treat both community-acquired and severe hospital-acquired infections.2 The first quinolone antibiotic is generally considered to
Discovery and Characterization of a Novel Series of
Jun 25, 2022We describe the identification and characterization of a series of covalent inhibitors of the C-terminal kinase domain (CTKD) of MSK1. The initial hit was identified via a high-throughput screening and represents a rare example of a covalent inhibitor which acts via an SNAr reaction of a 2,5-dichloropyrimidine with a cysteine residue (Cys440). The covalent

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