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Pathogenesis of Helicobacter pylori Infection
Helicobacter pylori is the first formally recognized bacterial carcinogen and is one of the most successful human pathogens, as over half of the world's population is colonized with this gram-negative bacterium. Unless treated, colonization usually persists lifelong. H. pylori infection represents a key factor in the etiology of various gastrointestinal diseases, ranging from
Globular Protein - an overview | ScienceDirect Topics
Globular proteins are named for their approximately spherical shapes and are the most abundant proteins in nature. The globular proteins exist in an enormous variety of three-dimensional structures. Nearly all globular proteins contain substantial numbers of α-helices and β-sheets folded into a compact structure that is stabilized by both polar and nonpolar interactions (Fig.
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Biomolecules | Free Full-Text | Design of Inhibitors of
Oct 03, 2021Intrinsically disordered proteins (IDPs) are emerging as attractive drug targets by virtue of their physiological ubiquity and their prevalence in various diseases, including cancer. NUPR1 is an IDP that localizes throughout the whole cell, and is involved in the development and progression of several tumors. We have previously repurposed trifluoperazine (TFP) as a drug
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x National guidelines recommend that maternity systems provide patient-centered access to immediate postpartum long-acting reversible contraception (i.e., insertion of an intrauterine device or implant during the delivery hospitalization). Hospitals face significant barriers to offering these services, and efforts to improve peripartum contraception care quality have met with mixed
ex-post facto research: Topics by Science
Designing research: ex post facto designs. PubMed. Giuffre, M. 1997-06-01. The research design is the overall plan or structure of the study. The goal of a good research design is to insure internal validity and answer the question being asked. The only clear rule in selecting a design is that the question dictates the design.
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