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Feb 08, 2022IDM H&S committee meetings for 2022 will be held via Microsoft Teams on the following Tuesdays at 12h30-13h30: 8 February 2022; 31 May 2022; 2 August 2022
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Lactic acid promotes PD-1 expression in regulatory T - Cancer Cell
Jan 27, 2022The balance of programmed death-1 (PD-1)-expressing CD8 + T cells and regulatory T (Treg) cells in the tumor microenvironment (TME) determines the clinical efficacy of PD-1 blockade therapy through the competition of their reactivation. However, factors that determine this balance remain unknown. Here, we show that Treg cells gain higher PD-1
Neoantigen-specific CD4+ T cells in human melanoma have
Apr 11, 2022Because isolation of tumor-specific T cells from tumor-infiltrating lymphocytes (TILs) or blood is challenging, we employed multiple approaches to identify and validate TCRVb sequences of neoantigen-specific CD4 + T cells (Figure S1A). PD-1 high CD4 + T cells, which have been shown to be enriched for tumor reactivity (Yossef et al., 2018), were sorted from

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